software
ForcedSwimScan
ForcedSwimScan is a component of our DepressionScan Suite. The forced swim test, as originally described by Porsolt et al, is the most widely used pharmacological method assessing antidepressant activity. This is largely due to its ease to use, reliability across laboratories, and ability to detect a broad spectrum of antidepressants.
ForcedSwimScan, not only provides more accurate results, but is also able to support the “Extended Forced Swim Test”, measuring the time spent struggling/ escaping/ climbing/ diving versus time spent floating/ immobile/ passive swimming in a tall cylinder filled with water.
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Features.
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Detected Behaviors.
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Applications:
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Fully automated complete Forced Swim Analysis
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Side‐view based analysis for accurate analysis
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Extended Forced Swim Test Protocol
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Real‐time or offline
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Easy setup with design tools
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No user intervention required during experiment
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Detailed statistics about the activity that occurred during the experiment
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Automated Binned Data analysis
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Validated with respect to human observation, as well as pharmacologically
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High‐Throughput capable with 4 tanks simultaneously
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Detection and analysis of body parts to allow more flexibility for user to define which activity is which
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Automatic adaptation to dynamic water surface typical of such experiments
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Result review, Visualization of Acquired Experiments
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Batch‐mode allows user to run multiple videos successively without human intervention
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Escape/Struggle
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Climb
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Full Dive
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Depression Analysis
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Immobile/Float
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Passive Dive
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Swim
Advanced Behavioral Insights
Clever Sys automates the Forced Swim Test to eliminate manual scoring variability and observer bias. Our AI-driven platform classifies complex mobility states—including struggling, escaping, climbing, diving, and floating/ immobile/ passive swimming—with sub-second precision. By delivering high-throughput, objective behavioral metrics, we provide the robust data integrity required for GLP compliance and the acceleration of preclinical CNS drug discovery pipelines.
Tech Details
• Platform: Win 11/10
• Software: ForcedSwimScan
• Hardware: Forced Swim Apparatus
Publications(partial)
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Kong, Pr., Gan, L., Zhang, Jl. et al. A modified tail suspension test for the assessment of behavioral despair in mice after stroke. Acta Pharmacol Sin 47, 1488 – 1500 (2026).
https://doi.org/10.1038/s41401-025-01735-z. -
Roger B Varela, Heather Macpherson, Adam J Walker, Tristan Houghton, Clarissa Yates, Nathanael J Yates, Venea D Daygon, Susannah J Tye. Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats. Brain, Behavior, and Immunity,
Volume 127, 2025, Pages 170-182, ISSN 0889-1591,
https://doi.org/10.1016/j.bbi.2025.03.001.. -
Wang H, Ma Z, Shen H, Wu Z, Liu L, Ren B, Wong P, Sethi G, Tang F. Early Life Irradiation-Induced Hypoplasia and Impairment of Neurogenesis in the Dentate Gyrus and Adult Depression Are Mediated by MicroRNA- 34a-5p/T-Cell Intracytoplasmic Antigen-1 Pathway. Cells. 2021; 10(9):2476. https://doi.org/10.3390/cells10092476..
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Optimized Windows Software
Proven Academic Trust
Our technology represents the industry benchmark for automated behavior testing. Scientific teams across the globe have published findings based on Clever Sys tech, adhering to strict preclinical compliance protocols while ensuring the highest level of data integrity and objectivity within prestigious international journals.
Precision Analytics
High-resolution tracking engines delivering granular spatial data for complex behavioral phenotyping.
Instant Data Access
Dynamic processing enables immediate visualization and rapid validation of experimental trial flows.
Preclinical Compliance
Engineered to satisfy rigorous regulatory mandates for reproducible and valid preclinical research.
Seamless Integration
Modular architecture ensures interoperability with established lab infrastructure and data pipelines.