behavior PARADIGM/test
Social Fear Conditioning
The Social Fear Conditioning (SFC) paradigm is a vital tool in behavioral neuroscience for assessing social fear conditioning and avoidance in animal models. This test offers deep insights into the neurobiological roots of anxiety by tracking freezing responses to social stimuli. Clever Sys modernizes this approach with advanced, video-based software that provides automated quantification, effectively replacing subjective manual scoring. Utilizing high-definition computer vision, our technology identifies subtle freezing and avoidance markers with sub-second accuracy, ensuring objective, high-throughput results. This automation eliminates observer bias and fatigue, facilitating the efficient study of large experimental groups while meeting strict preclinical standards. Our precision-engineered systems support reproducible research across various laboratories, offering a robust platform for consistent behavioral phenotyping. By choosing Clever Sys, researchers measure avoidance with unmatched clarity, enhancing the scientific integrity of psychiatric research and drug discovery initiatives.
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Typical Behavior Events
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Social Approach
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Social Sniff
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Sniffing on Object (Area)
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Freezing
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Validated Precision:Â Â Â Â Â Used by top scientists to meet preclinical compliance and produce robust, verifiable research data.
Traditional Methods
Manual Scoring
Observer Bias
Basic Insights
Time-ConsumingÂ
Clever Sys AI
Fully Automated
Objective & Precise
Deep Data Analytics
Real-Time Analysis and Instant Results
Advanced Behavioral Insights
Clever Sys automates the Social Fear Conditioning (SFC) paradigm by applying advanced computer vision to detect and quantify social fear responses from video. Our technology replaces manual scoring with objective, high-throughput analysis of freezing behavior and social avoidance. By processing experimental video in real-time, the system ensures precision and preclinical compliance, providing researchers with reliable data for psychiatric drug discovery.
Tech Details
• Platform:    Win 11/10
• Software:   TopScan (with License for Corresponding Modules)
• Hardware:  Social Freezing Test Apparatus
Optimized Windows Software
Proven Academic Trust
Our technology represents the industry benchmark for automated behavior testing. Scientific teams across the globe have published findings based on Clever Sys tech, adhering to strict preclinical compliance protocols while ensuring the highest level of data integrity and objectivity within prestigious international journals.
Publications
See high-fidelity AI-Powered Social Fear Conditioning Analysis in action: capturing exploration with sub-second precision to maintain rigorous preclinical standards.
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Elizabeth A. Kleeman, Carolina Gubert, Sonali N. Reisinger, Kathryn C. Davidson, Da Lu, Merle Dayton, Liana Mackiewicz, Bethany A. Masson, Pranav Adithya, Alexandra L. Garnham, Gemma Stathatos, Moira K. O ’ Bryan, Rikeish R. Muralitharan, Francine Z. Marques, Shanshan Li, Huan Liao, Shae McLaughlin, Emmet T. Keough, Michelle Y. Wheeler, Pamudika Kiridena, Marcel Doerflinger, Marc Pellegrini, Anthony J. Hannan. Paternal SARSCoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner. Nature Communications, volume 16, Article number: 9045 (2025) .
https://www.nature.com/articles/s41467-025-64473-0#citeas.. -
Xu-Yi Li, Shi-Ya Zhang, Yi-Zhou Hong, Su Su Tang, tang_susu@126.com, Hao Wang, wanghao890625@126.com, Hao Hong, honghao@cpu.edu.cn. TGR5-mediated lateral hypothalamus-dCA3-dorsolateral septum circuit regulates depressive-like behavior in male
mice. Neuron, Volume 112, Issue 11p1795-1814.e10, June 05, 2024
https://www.cell.com/neuron/fulltext/S0896-6273(24)00152-1. -
Christine Ochoa Escamilla, Irina Filonova, Angela K. Walker, Zhong X. Xuan, Roopashri Holehonnur, Felipe Espinosa, Shunan Liu, Summer B. Thyme, Isabel A. López-GarcÃa, Dorian B. Mendoza, Noriyoshi Usui, Jacob Ellegood, Amelia J. Eisch, Genevieve Konopka, Jason P. Lerch, Alexander F. Schier, Haley E. Speed & Craig M. Powell (2017) Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017 Nov 9;551(7679):227-231. doi: 10.1038/nature24470. Epub 2017 Nov 1. PMID: 29088697; PMCID: PMC5787033
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Precision Analytics
High-resolution tracking engines delivering granular spatial data for complex behavioral phenotyping.
Instant Data Access
Dynamic processing enables immediate visualization and rapid validation of experimental trial flows.
Preclinical Compliance
Engineered to satisfy rigorous regulatory mandates for reproducible and valid preclinical research.
Seamless Integration
Modular architecture ensures interoperability with established lab infrastructure and data pipelines.