
behavior PARADIGM/test
Thermal Gradient Test
The Thermal Gradient Test is a sophisticated behavioral paradigm essential for evaluating thermotaxis and thermal preference in rodent models. By providing a continuous temperature range, researchers can identify subtle nociceptive thresholds and thermoregulatory shifts, making it a pivotal assay in pain research, metabolic studies, and neuro-pharmacological drug discovery. Understanding how subjects navigate these gradients provides profound insights into the physiological and neural mechanisms underlying sensory processing.Clever Sys advances this research with an automated system that integrates high-precision thermal control with advanced video tracking. Our technology eliminates human error and the limitations of manual observation by providing real-time, high-throughput quantification of stay duration, movement patterns, and temperature preference. Designed for laboratory efficiency, this automated platform ensures superior data integrity, providing the reproducible indicators and rigorous evidence required for preclinical compliance and high-impact publication.
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Automated Analytics:Â Â Â Â Advanced tracking algorithm removes subjective bias .
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Advanced Features:Â Â Â Â Â Accurate Animal Detection and Tracking.Â
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Validated Precision:Â Â Â Â Used by top scientists to meet preclinical compliance and produce robust, verifiable research data.



Traditional Methods


Manual Scoring

Observer Bias

Basic Insights
Time-ConsumingÂ
Clever Sys AI


Fully Automated

Objective & Precise

Deep Data Analytics
Real-Time Analysis and Instant Results

Advanced Behavioral Insights
Automating the Thermal Gradient Test via Clever Sys eliminates the subjectivity of manual temperature zoning. Neuroscience researchers leverage our advanced tracking to monitor thermotaxis and preference across a precise thermal range with exceptional accuracy. By capturing continuous movement and residence time data, our platform produces the objective metrics necessary for valid preclinical assessment and CNS drug discovery trials.
Tech Details
• Platform:    Win 11/10
• Software:   TopScan
• Hardware:  Thermal Gradient Test Apparatus

Optimized Windows Software
Proven Academic Trust
Our technology represents the industry benchmark for automated behavior testing. Scientific teams across the globe have published findings based on Clever Sys tech, adhering to strict preclinical compliance protocols while ensuring the highest level of data integrity and objectivity within prestigious international journals.
Publications
See high-fidelity AI-Powered Thermal Gradient Test Analysis in action: capturing exploration with sub-second precision to maintain rigorous preclinical standards.
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Aron, L., Ngian, Z.K., Qiu, C. et al. Lithium deficiency and the onset of Alzheimer’s disease. Nature 645, 712–721 (2025). https://doi.org/10.1038/s41586-025-09335-x.Â
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Tian Z, Song J, Zhao X, Zhou Y, Chen X, Le Q, Wang F, Ma L, Liu X. The interhemispheric amygdala-accumbens circuit encodes negative valence in mice. Science. 2024 Nov 8;386(6722):eadp7520. doi: 10.1126/science.adp7520. Epub 2024 Nov 8. PMID:39509508.
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Escamilla CO, Filonova I, Walker AK, Xuan ZX, Holehonnur R, Espinosa F, Liu S, Thyme SB, López-GarcÃa IA, Mendoza DB, Usui N, Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE, Powell CM. Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017 Nov 9;551(7679):227-231. doi: 10.1038/nature24470. Epub 2017 Nov 1. PMID: 29088697; PMCID: PMC5787033.
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Precision Analytics
High-resolution tracking engines delivering granular spatial data for complex behavioral phenotyping.

Instant Data Access
Dynamic processing enables immediate visualization and rapid validation of experimental trial flows.

Preclinical Compliance
Engineered to satisfy rigorous regulatory mandates for reproducible and valid preclinical research.

Seamless Integration
Modular architecture ensures interoperability with established lab infrastructure and data pipelines.


Maximum Resolution
Sophisticated sensor networks providing high-fidelity tracking of delicate physiological data points.

Instant Data Flow
Smart logic modules deliver immediate visual feedback for faster decision-making in laboratory settings.

Preclinical Compliance
Built to fulfill rigorous laboratory and regulatory benchmarks for robust engineering quality.

Flexible Interface
Interconnected hardware modules designed to work within diverse lab networks and external data systems.
