behavior PARADIGM/test
IVCRackScan: Circadian Rhythm on IVC RackÂ
The IVCRackScan technology provides a fully automated, high-throughput solution for monitoring rodent HomeCage behavior directly within existing ventilated rack systems, specifically designed for intensive preclinical studies. Utilizing sophisticated AI-driven video analytics, it performs continuous 24/7 observation of activity levels and postural changes, capturing detailed data on circadian rhythmicity, sleep-wake cycles, and behavior patterns without human disruption. These objective, longitudinal metrics support the identification of subtle disruptions in biological clocks, onset of disease symptoms, and therapeutic responses that intermittent manual checks frequently overlook. Operating within the animal's home cage environment ensures maximum data validity across large experimental groups and multi-site trials. IVCRackScan is an essential tool for behavioral neuroscience, toxicology, and metabolic research where non-invasive, high-throughput phenotyping is required to achieve rigorous scientific standards and generate high-impact, verifiable research results.
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Detected Behaviors.
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Rear Up
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Come Down
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Walk/Run
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Hang
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Jump
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Land
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Turn.
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Eat
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Drink
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Chew
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Sniff
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Dig
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Forage
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Circle
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Groom
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Stretch
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Sleep
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Twitch
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Pause
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Awaken
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Urinate
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Applications
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Disease Progression Studies
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Stereotypic Behavior Studies
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Genetic Research
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Toxicology Studies
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Foot/Liquid Intake Studies
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Obesity/Metabolism Studies
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Pain & Motor Deficiency
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Aging/Longitudinal Studies
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Validated Precision:Â Â Â Â Â Used by top scientists to meet preclinical compliance and produce robust, verifiable research data.
Traditional Methods
Manual Scoring
Observer Bias
Basic Insights
Time-ConsumingÂ
Clever Sys AI
Fully Automated
Objective & Precise
Deep Data Analytics
Real-Time Analysis and Instant Results
Advanced Behavioral Insights
Automating circadian rhythm analysis via IVCRackScan eliminates human interference and longitudinal data gaps. Neuroscience researchers utilize our system to monitor 24/7 activity and rest cycles with precise detail. By analyzing behavioral shifts directly on the IVC rack, our platform delivers objective longitudinal evidence necessary for stringent preclinical compliance and identifying metabolic or neurological markers.
Tech Details
• Platform:    Win 11/10
• Software:   HomeCageScan
• Hardware:  Customized IVC-Rack Apparatus
Optimized Windows Software
Proven Academic Trust
Our technology represents the industry benchmark for automated behavior testing. Scientific teams across the globe have published findings based on Clever Sys tech, adhering to strict preclinical compliance protocols while ensuring the highest level of data integrity and objectivity within prestigious international journals.
See high-fidelity AI-Powered Home Cage Analysis (on IVC-Rack) in action: capturing exploration with sub-second precision to maintain rigorous preclinical standards.
Publications
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Li Y, Cacciottolo TM, Yin N, He Y, Liu H, Liu H, Yang Y, Henning E, Keogh JM, Lawler K, Mendes de Oliveira E, Gardner EJ, Kentistou KA, Laouris P, Bounds R, Ong KK, Perry JRB, Barroso I, Tu L, Bean JC, Yu M, Conde KM, Wang M, Ginnard O, Fang X, Tong L, Han J, Darwich T, Williams KW, Yang Y, Wang C, Joss S, Firth HV, Xu Y, Farooqi IS. Loss of transient receptor potential channel 5 causes obesity and postpartum depression. Cell. 2024 Aug 8;187(16):4176-4192.e17. doi: 10.1016/j.cell.2024.06.001. Epub 2024 Jul 2. PMID: 38959890; PMCID: PMC11961024.
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Wang QC, Zheng Q, Tan H, Zhang B, Li X, Yang Y, Yu J, Liu Y, Chai H, Wang X, Sun Z, Wang JQ, Zhu S, Wang F, Yang M, Guo C, Wang H, Zheng Q, Li Y, Chen Q, Zhou A, Tang TS (2016) . TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel, Cell. 2016 Jun 2;165(6):1454-66. doi: 10.1016/j.cell.2016.04.051. Epub 2016 May 19.
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Dietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding. Cell. 2015 Mar 12;160(6):1222-32. doi: 10.1016/j.cell.2015.02.024. Epub 2015 Mar 5. Erratum in: Cell. 2017 Apr 20;169(3):559. doi: 10.1016/j.cell.2017.04.006. PMID: 25748653; PMCID: PMC4484787.
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Hua Y, Sahashi K, Rigo F, Hung G, Horev G, Bennett CF, Krainer AR (2011) , Peripheral SMN restoration is essential for long-term rescue of a severe spinal muscular atrophy mouse model, Nature. 2011 Oct 5;478(7367):123-6. doi: 10.1038/nature10485
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Chen, D., Steele, A. D., Lindquist, S., & Guarente, L. (2005). Increase in activity during calorie restriction requires Sirt1. Science, 310(5754), 1641
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Precision Analytics
High-resolution tracking engines delivering granular spatial data for complex behavioral phenotyping.
Instant Data Access
Dynamic processing enables immediate visualization and rapid validation of experimental trial flows.
Preclinical Compliance
Engineered to satisfy rigorous regulatory mandates for reproducible and valid preclinical research.
Seamless Integration
Modular architecture ensures interoperability with established lab infrastructure and data pipelines.