behavior PARADIGM/test
Fear Conditioning
Fear conditioning is an essential pillar of behavioral neuroscience, providing a robust experimental framework for quantifying associative learning and emotional memory. By systematically pairing neutral environmental cues with aversive stimuli, researchers can precisely measure conditioned fear responses in rodent models.
Â
Our advanced systems optimize this paradigm by automating the detection of freezing behavior and contextual discrimination, eliminating manual scoring errors. For preclinical researchers, this technology ensures high-throughput efficiency and exceptional data reproducibility, making it an indispensable tool for characterizing phenotypic traits, screening pharmacological candidates, and investigating the neurological underpinnings of memory formation in rigorous laboratory environments.
-
Automated Analytics:Â Advanced motion analysis algorithm removes subjective bias during fear conditioning test.
-
Advanced Features:    Support sound file as audio cue besides tone and white noise; Interval metric calculation and export; Memory Extinction. Â
-
Validated Precision:Â Â Â Â Used by top scientists to meet preclinical compliance and produce robust, verifiable research data.
Traditional Methods
Manual Scoring
Observer Bias
Basic Insights
Time-ConsumingÂ
Clever Sys AI
Fully Automated
Objective & Precise
Deep Data Analytics
Real-Time Analysis and Instant Results
Advanced Behavioral Insights
Clever Sys automates Fear Conditioning to eliminate scoring bias and inter-observer variability. Our validated technology enables researchers to quantify associative learning and memory with high-throughput efficiency and sub-second precision. By delivering instant, objective data, we provide the robust evidence necessary for preclinical regulatory compliance and the acceleration of CNS-related drug discovery and neurobehavioral phenotyping.
Tech Details
• Platform:    Win 11/10
• Software:   FreezeScan
• Hardware:  Fear Conditoning Apparatus
Optimized Windows Software
Proven Academic Trust
Our technology represents the industry benchmark for automated behavior testing. Scientific teams across the globe have published findings based on Clever Sys tech, adhering to strict preclinical compliance protocols while ensuring the highest level of data integrity and objectivity within prestigious international journals.
Publications
See high-fidelity AI-Powered Freezing Analysis in action: capturing exploration with sub-second precision to maintain rigorous preclinical standards.
​
-
Shi, S.M., Suh, R.J., Shon, D.J. et al. Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease. Nature 639, 985–994 (2025). https://doi.org/10.1038/s41586-025-08589-9.Â
-
John V. Pluvinage, Michael S. Haney, Benjamin A. H. Smith, Jerry Sun, Tal Iram, Liana Bonanno, Lulin Li, Davis P. Lee, David W. Morgens, Andrew C. Yang, Steven R.Shuken, David Gate, Madeleine Scott, Purvesh Khatri, Jian Luo, Carolyn R. Bertozzi, Michael C. Bassik & Tony Wyss-Coray (2019) CD22 blockade restores homeostatic microglial phagocytosis in ageing brains, Nature volume 568, pages187–192 (2019).
-
Joseph M. Castellano, Kira I. Mosher, Rachelle J. Abbey, Alisha A. McBride, Michelle L. James, Daniela Berdnik, Jadon C. Shen, Bende Zou, Xinmin S. Xie, Martha Tingle, Izumi V. Hinkson, Martin S. Angst & Tony Wyss-Coray (2017) Human umbilical cord plasma proteins revitalize hippocampal function in aged mice,  Nature (2017), doi:10.1038/nature22067.
-
.....
Precision Analytics
High-resolution tracking engines delivering granular spatial data for complex behavioral phenotyping.
Instant Data Access
Dynamic processing enables immediate visualization and rapid validation of experimental trial flows.
Preclinical Compliance
Engineered to satisfy rigorous regulatory mandates for reproducible and valid preclinical research.
Seamless Integration
Modular architecture ensures interoperability with established lab infrastructure and data pipelines.