
behavior PARADIGM/test
Active/Passive Avoidance
Active and Passive Avoidance paradigms serve as critical benchmarks in behavioral neuroscience for evaluating associative learning and memory retention. In Active Avoidance, subjects must perform a specific action to bypass an aversive stimulus, whereas Passive Avoidance measures the suppression of an innate response to avoid consequences. Clever Sys provides sophisticated, fully automated systems that transform these complex preclinical research workflows.
By integrating high-precision tracking and real-time motion analytics, our technology removes the subjectivity of manual scoring while ensuring consistent, high-throughput data collection. Behavioral neuroscience labs worldwide rely on these automated solutions to achieve superior reproducibility and accuracy, facilitating deeper insights into neuropharmacological effects and the cognitive mechanisms underlying memory formation within rigorous, modern experimental environments.
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Automated Analytics:Â Â Advanced tracking algorithm removes subjective bias during active and passive avoidance test.
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Advanced Features:Â Â Â Handling Noise and Lighting Changes, Support Protocol Stage Based Events, Â
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Validated Precision:Â Â Â Â Used by top scientists to meet preclinical compliance and produce robust, verifiable research data.



Traditional Methods


Manual Scoring

Observer Bias

Basic Insights
Time-ConsumingÂ
Clever Sys AI


Fully Automated

Objective & Precise

Deep Data Analytics
Real-Time Analysis and Instant Results

Advanced Behavioral Insights
Clever Sys automates Active and Passive Avoidance tasks to eliminate observer variance and manual scoring errors. Our high-throughput platform accelerates the characterization of learning and memory paradigms through real-time kinematic analysis. By delivering objective, reproducible datasets, we empower researchers to meet stringent preclinical standards and streamline drug discovery pipelines for complex CNS and neurocognitive disorders.
Tech Details
• Platform:    Win 11/10
• Software:   TopScan
• Hardware:  Shuttle Box Apparatus

Optimized Windows Software
Proven Academic Trust
Our technology represents the industry benchmark for automated behavior testing. Scientific teams across the globe have published findings based on Clever Sys tech, adhering to strict preclinical compliance protocols while ensuring the highest level of data integrity and objectivity within prestigious international journals.
Publications
See high-fidelity AI-Powered Shuttle Box Test Analysis in action: capturing exploration with sub-second precision to maintain rigorous preclinical standards.
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Aron, L., Ngian, Z.K., Qiu, C. et al. Lithium deficiency and the onset of Alzheimer’s disease. Nature 645, 712–721 (2025). https://doi.org/10.1038/s41586-025-09335-x.Â
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Tian Z, Song J, Zhao X, Zhou Y, Chen X, Le Q, Wang F, Ma L, Liu X. The interhemispheric amygdala-accumbens circuit encodes negative valence in mice. Science. 2024 Nov 8;386(6722):eadp7520. doi: 10.1126/science.adp7520. Epub 2024 Nov 8. PMID:39509508.
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Escamilla CO, Filonova I, Walker AK, Xuan ZX, Holehonnur R, Espinosa F, Liu S, Thyme SB, López-GarcÃa IA, Mendoza DB, Usui N, Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE, Powell CM. Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017 Nov 9;551(7679):227-231. doi: 10.1038/nature24470. Epub 2017 Nov 1. PMID: 29088697; PMCID: PMC5787033.
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Precision Analytics
High-resolution tracking engines delivering granular spatial data for complex behavioral phenotyping.

Instant Data Access
Dynamic processing enables immediate visualization and rapid validation of experimental trial flows.

Preclinical Compliance
Engineered to satisfy rigorous regulatory mandates for reproducible and valid preclinical research.

Seamless Integration
Modular architecture ensures interoperability with established lab infrastructure and data pipelines.

