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Automated Circling/Rotational Behavior Analysis

Our sophisticated tracking technology automates circling/rotational analysis to deliver unmatched objectivity and sensitivity in pharmacological screening. This high-throughput system eliminates observer bias, ensuring precise results for your research.

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behavior PARADIGM/test

Circling

Circling behavior or rotational locomotion is a cornerstone behavioral paradigm used to evaluate unilateral brain dysfunction and motor asymmetries in animal models. This test is essential in neuroscience and pharmacology for assessing the effects of localized lesions or drug interventions on the nigrostriatal dopaminergic system. By measuring the frequency and direction of rotations, researchers gain critical insights into neural pathway integrity and the therapeutic potential of neuroprotective compounds. This quantitative approach is fundamental for studying Parkinson’s disease, stroke, and sensory deficits where lateralized motor control is impacted.Clever Sys provides an advanced automated circling analysis system that utilizes sophisticated motion tracking and computer vision algorithms to record rotational metrics with absolute objectivity. By replacing manual tallying with high-precision digital oversight, our technology eliminates observer bias and captures subtle behavioral fluctuations that human eyes might miss. This high-throughput capability ensures rigorous data integrity and preclinical compliance, providing scientific teams with the robust, verifiable data required for high-impact publications and accelerated drug discovery workflows.

  • Automated Analytics:    Advanced heading direction algorithm removes subjective bias.

  • Advanced Features:          Accurate Circling Detection and Associated Metrics. 

  • Validated Precision:       Used by top scientists to meet preclinical compliance and produce robust, verifiable research data.

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Traditional Methods

Manual Scoring

Observer Bias

Basic Insights

Time-Consuming 

Clever Sys AI

Fully Automated

Objective & Precise

Deep Data Analytics

Real-Time Analysis and Instant Results

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Advanced Behavioral Insights

Clever Sys automates circling behavior analysis by utilizing high-resolution tracking to eliminate the inconsistencies of manual scoring. This advanced platform allows pharmacology and neuroscience researchers to quantify rotational locomotion with extreme precision and reproducibility. By delivering sensitive, objective metrics in real-time, our solution ensures data integrity for preclinical compliance and enhances drug discovery workflows.

Tech Details

• Platform:       Win 11/10

• Software:     TopScan (with License for Corresponding Modules)

• Hardware:    Testing Apparatus

Optimized Windows Software

Proven Academic Trust

Our technology represents the industry benchmark for automated behavior testing. Scientific teams across the globe have published findings based on Clever Sys tech, adhering to strict preclinical compliance protocols while ensuring the highest level of data integrity and objectivity within prestigious international journals.

Publications

See high-fidelity AI-Powered Circling Detection and  Analysis in action: capturing exploration with sub-second precision to maintain rigorous preclinical standards.

  • Aron, L., Ngian, Z.K., Qiu, C. et al. Lithium deficiency and the onset of Alzheimer’s disease. Nature 645, 712–721 (2025). https://doi.org/10.1038/s41586-025-09335-x. 

  • Tian Z, Song J, Zhao X, Zhou Y, Chen X, Le Q, Wang F, Ma L, Liu X. The interhemispheric amygdala-accumbens circuit encodes negative valence in mice. Science. 2024 Nov 8;386(6722):eadp7520. doi: 10.1126/science.adp7520. Epub 2024 Nov 8. PMID:39509508.

  • Escamilla CO, Filonova I, Walker AK, Xuan ZX, Holehonnur R, Espinosa F, Liu S, Thyme SB, López-García IA, Mendoza DB, Usui N, Ellegood J, Eisch AJ, Konopka G, Lerch JP, Schier AF, Speed HE, Powell CM. Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017 Nov 9;551(7679):227-231. doi: 10.1038/nature24470. Epub 2017 Nov 1. PMID: 29088697; PMCID: PMC5787033.

  • .....

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Precision Analytics

High-resolution tracking engines delivering granular spatial data for complex behavioral phenotyping.

Instant Data Access

Dynamic processing enables immediate visualization and rapid validation of experimental trial flows.

Preclinical Compliance

Engineered to satisfy rigorous regulatory mandates for reproducible and valid preclinical research.

Seamless Integration

Modular architecture ensures interoperability with established lab infrastructure and data pipelines.

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