
behavior PARADIGM/test
Empathy Test
The Empathy Chamber is a behavioral apparatus used in neuroscience research, often featuring a two- or three-chamber design to measure social empathy, social fear learning, and emotional contagion in rodents. It typically assesses an observer animal's response to a distressed conspecific, such as through freezing behavior, to study empathy-like reactions.
The Empathy Chamber Test system by Clever Sys provides a specialized environment for conducting automated rodent empathy experiments with unmatched precision and consistency. By unifying high-performance hardware, advanced tracking software, and robust data analytics, our solution allows researchers to achieve superior accuracy and throughput in their behavioral studies. At the core of the system is our proprietary video-based behavior recognition technology, which facilitates automated scoring to eliminate the subjective biases often found in manual observation. Designed specifically for preclinical neuroscience and pharmacology applications, the Empathy Chamber enables the seamless quantification of emotional contagion and social distress in real time. This ensures every trial is highly reproducible, meeting the stringent requirements of pharmaceutical drug discovery and academic inquiry. Trusted by world-renowned academic institutions and leading pharma labs across the globe, Clever Sys delivers the reliable instrumentation necessary to decode complex social interactions efficiently, accelerating breakthroughs in central nervous system research and behavioral health development.
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Automated Analytics:Â Advanced motion analysis algorithm removes subjective bias during fear conditioning test.
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Advanced Features:    Support sound file as audio cue besides tone and white noise; Interval metric calculation and export; Memory Extinction. Â
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Validated Precision:Â Â Â Â Used by top scientists to meet preclinical compliance and produce robust, verifiable research data.



Traditional Methods


Manual Scoring

Observer Bias

Basic Insights
Time-ConsumingÂ
Clever Sys AI


Fully Automated

Objective & Precise

Deep Data Analytics
Real-Time Analysis and Instant Results

Advanced Behavioral Insights
Clever Sys automates Fear Conditioning to eliminate scoring bias and inter-observer variability. Our validated technology enables researchers to quantify associative learning and memory with high-throughput efficiency and sub-second precision. By delivering instant, objective data, we provide the robust evidence necessary for preclinical regulatory compliance and the acceleration of CNS-related drug discovery and neurobehavioral phenotyping.
Tech Details
• Platform:    Win 11/10
• Software:   FreezeScan
• Hardware:  Empathy Test Chamber

Optimized Windows Software
Proven Academic Trust
Our technology represents the industry benchmark for automated behavior testing. Scientific teams across the globe have published findings based on Clever Sys tech, adhering to strict preclinical compliance protocols while ensuring the highest level of data integrity and objectivity within prestigious international journals.
See high-fidelity AI-Powered Freezing Detection and Analysis in action: capturing exploration with sub-second precision to maintain rigorous preclinical standards.
Publications
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Shi, S.M., Suh, R.J., Shon, D.J. et al. Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease. Nature 639, 985–994 (2025). https://doi.org/10.1038/s41586-025-08589-9.Â
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John V. Pluvinage, Michael S. Haney, Benjamin A. H. Smith, Jerry Sun, Tal Iram, Liana Bonanno, Lulin Li, Davis P. Lee, David W. Morgens, Andrew C. Yang, Steven R.Shuken, David Gate, Madeleine Scott, Purvesh Khatri, Jian Luo, Carolyn R. Bertozzi, Michael C. Bassik & Tony Wyss-Coray (2019) CD22 blockade restores homeostatic microglial phagocytosis in ageing brains, Nature volume 568, pages187–192 (2019).
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Joseph M. Castellano, Kira I. Mosher, Rachelle J. Abbey, Alisha A. McBride, Michelle L. James, Daniela Berdnik, Jadon C. Shen, Bende Zou, Xinmin S. Xie, Martha Tingle, Izumi V. Hinkson, Martin S. Angst & Tony Wyss-Coray (2017) Human umbilical cord plasma proteins revitalize hippocampal function in aged mice,  Nature (2017), doi:10.1038/nature22067.
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Precision Analytics
High-resolution tracking engines delivering granular spatial data for complex behavioral phenotyping.

Instant Data Access
Dynamic processing enables immediate visualization and rapid validation of experimental trial flows.

Preclinical Compliance
Engineered to satisfy rigorous regulatory mandates for reproducible and valid preclinical research.

Seamless Integration
Modular architecture ensures interoperability with established lab infrastructure and data pipelines.
